Dicobaltoctacarbonyl-alkyne complexes as intermediates in the synthesis of bicyclo[3.3.0]octenones for the synthesis of coriolin and hirsutic acid期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Dicobaltoctacarbonyl-alkyne complexes as intermediates in the synthesis of bicyclo[3.3.0]octenones for the synthesis of coriolin and hirsutic acid

Authors:	Philip Magnus Christopher Exon Pamela Albaugh-Robertson

Affiliation:	Department of Chemistry, Indiana University, Bloomington, IN 47405, U.S.A

Abstract:	Treatment of the readily prepared enzymes 12, 21 and 45 with Co₂(CO) at ca 110° results in high yields (80%) of substituted bicyclo[3.3.0]octenones, that are suitable for straightforward elaboration into coriolin and hirsutic acid precursors. A mechanistic hypothesis to explain the observed stereospecificity is presented.

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