Synthesis,DNA binding and oxidative cleavage studies of an asymmetric tridentate copper(II) complex |
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| Authors: | Xiang-Li Wang Hui Chao Bin Peng Liang-Nian Ji Jian Zhang |
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| Institution: | (1) Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, P.R. China;(2) The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510275, P.R. China |
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| Abstract: | An asymmetric tridentate CuII complex, Cu(ptp)Cl2] (ptp = 3-(1,10-phenanthrolin-2-yl)-as-triazino5,6-f]-phenanthrene), has been synthesized and characterized by elemental analysis, FAB-MS, i.r. and u.v.–vis. spectra.
The DNA binding behavior of the complex has been examined by fluorescence quenching, cyclic voltammetric and viscosity measurements.
The results suggest that Cu(ptp)Cl2] binds to DNA in the intercalative mode. This complex is also found to produce cleavage of pBR 322 DNA in the presence of
reducing agents such as ascorbate/H2O2, and the hydroxyl radical (OH•) is suggested to be the reactive species responsible for the cleavage. |
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