| Raman spectroscopic identification of normal and malignant human stomach cells |
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| 作者姓名： | 杨继朋 郭建宇 吴良平 孙真荣 蔡炜颖 王祖赓 |
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| 作者单位： | Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University) Ministry of Education，Department of Physics，and Department of Chemistry，East China Normal University，Shanghai 200062，Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University)，Ministry of Education，Department of Physics，and Department of Chemistry，East China Normal University，Shanghai 200062，Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University)，Ministry of Education，Department of Physics，and Department of Chemistry，East China Normal University，Shanghai 200062，Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University)，Ministry of Education，Department of Physics，and Department of Chemistry，East China Normal University，Shanghai 200062，Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University)，Ministry of Education，Department of Physics，and Department of Chemistry，East China Normal University，Shanghai 200062，Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University)，Ministry of Education，Department of Physics，and Department of Chemistry，East China Normal University，Shanghai 200062 |
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| 基金项目： | This work was supported by the National Natu-ral Science Foundation of China (No. 10234030 and 10374030) the National Key Project for Basic Research of China (No. 1999075204) the Shanghai Science and Technology Committee (No. 036105019)the Twilight Project sponsored by Shanghai Education Committee (No. 03SG23). |
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| 摘 要： | Micro-Raman spectroscopy is employed to identify the normal and malignant human stomach cells. For the cancer cell, the reduced intensity of the Raman peak at 1250 cm-1 indicates that the protein secondary structure transforms from β-sheet or disordered structures to α-helical, while the increased intensity of the symmetric PO2 stretching vibration mode at 1094 cm-1 shows the increased DNA content. The ratio of the intensity at 1315 cm-1 to that at 1340-1 reduces from 1.8 for the normal cell to 1.1 for the cancer cell in the course of canceration, and the ratio of the intensity at 1655 cm-1 to that at 1450cm-1 increases from 1.00 for the cancer cell to 1.26 for the normal cell which indicates that the canceration of stomach cell may induce saturation of the lipid chain.
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