Synthesisof Some Novel 2,6- Dimethoxyhydroquinone-3- mercaptoacetyl-peptide Conjugates as PotentialAntitumor Agents

2, 6 - D imethoxyhydroquinon e - 3 -mere aptoac et ic ac id (D M Q -MA) I -3 is a syntheti cderivative of 2, 6 - d imethoxyp -b enzoqu inone (D M Q )#, whi oh is a n atUral fermentedproduct of wheat germ and was found to have a wide spectrUm of cytotoxicity againstvarious tUmor cell lines under the synergistic activation of L-ascorbic acid as reported byG.A.Szents. Owing to the very low aqueous solubility of DMQ, which is an apparentdisadvantage for the development as a vaccine, we prep…

Synthesis of Some Novel 2,6- Dimethoxyhydroquinone-3- mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents

This paper reports an ongoing study of the use of short chain peptides as carriers of a potential antitumor agents: 2, 6 -dimethoxyhydroquinone -3 -mercaptoacetic acid (DMQ-MA). Three new peptide-DMQ-MA conjugates: DMQ-MA-arg-arg-ome, DMQ -MA- lys(cbz) -arg-ome,DMQ- MA-lys(cbz) -arg- arg- ome were synthesized by coupling protected amino acids in solution and the next conjugation was achieved by reacting with pentafluorophenyl ester of DMQ-MA in DMF, and further study on their ability to inhibit human pulmonary adenocarcinoma cell line (PC-9 cells) and oral epidermoid carcinoma cell line (KB) are investigating.