A convenient synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole based peptidomimetics employing diacylhydrazines derived from amino acids |
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| Authors: | G. Nagendra |
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| Affiliation: | Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Dr. B. R. Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India |
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| Abstract: | Synthesis of novel orthogonally protected 1,3,4-thiadiazole and 1,3,4-oxadiazole tethered dipeptide mimetics is described. Both the heterocycles are prepared via a set of diacylhydrazines derived from amino acids. 1,3,4-Thiadiazoles are synthesized by dehydrosulfurization using Lawesson’s reagent while 1,3,4-oxadiazoles are obtained by EDC mediated cyclodehydration. |
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| Keywords: | Peptidomimetics Diacylhydrazine Cyclization Thiadiazole Oxadiazole |
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