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Generation of pyrrolo[2,3-d]pyrimidines. Unexpected products in the multicomponent reaction of 6-aminopyrimidines, dimedone, and arylglyoxal |
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| Authors: | Jairo Quiroga Paola A Acosta Rodrigo Abonía Manuel Nogueras Justo Cobo |
| Institution: | a Grupo de Investigación de Compuestos Heterocíclicos, Department of Chemistry, Universidad del Valle, A.A. 25360, Cali, Colombia b Department of Chemistry, Universidad de Nariño, A.A. 1175, Pasto, Colombia c Department of Inorganic and Organic Chemistry, Universidad de Jaén, 23071 Jaén, Spain |
| Abstract: | A series of 6-aryl-5-(1-cyclohexen-1-yl)pyrrolo2,3-d]pyrimidines 9a-q were obtained by the three-component reaction between 6-aminopyrimidines 6, 7, 8, dimedone 2, and arylglyoxal 5a,b. The unexpected cyclization process was established by NMR and X-ray diffraction measurements. |
| Keywords: | Pyrrolopyrimidines Multicomponent reaction Aminopyrimidines Arylglyoxal Dimedone |
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