PEG-embedded thiourea dioxide (PEG.TUD) as a novel organocatalyst for the highly efficient synthesis of 3,4-dihydropyrimidinones |
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Authors: | Sanny Verma Bir Sain |
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Institution: | Chemical Sciences Division, Indian Institute of Petroleum (Council of Industrial & Scientific Research), Dehradun 248005, India |
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Abstract: | The host-guest complex between polyethylene glycol and thiourea dioxide (PEG.TUD) was prepared via different approaches involving co-crystallization method and by a chemical reaction. The resulting PEG.TUD complex was found to be very active and recyclable catalyst for the direct synthesis of 3,4-dihydropyrimidinones via Biginelli condensation and provided high product yields. Interestingly, the corresponding poly(ethylene glycol)-thiourea complexes, PEG.TU, were found to be unreactive and no reaction occurred under similar reaction conditions. |
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Keywords: | Host-guest complex Organocatalyst Thiourea Biginelli Green method |
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