An efficient synthesis of futalosine |
| |
Authors: | Xu Li |
| |
Affiliation: | University of British Columbia, Department of Chemistry, Vancouver, British Columbia, Canada V6T 1Z1 |
| |
Abstract: | Futalosine is a naturally occurring nucleoside comprised of an inosine core with a 3-carboxyphenyl methylene ketone functionality replacing the C-5′ hydroxyl. Recent studies have shown that it is a key intermediate in an alternative biosynthetic pathway that generates menaquinone in a variety of bacterial species. Here we report the first synthesis of futalosine in seven steps from inosine in an overall 17% yield. This work will enable further studies on menaquinone biosynthesis in pathogenic bacteria. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|