A short and efficient asymmetric synthesis of komaroviquinone |
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Authors: | Yutaka Suto Kento Kaneko Noriyuki Yamagiwa Genji Iwasaki |
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Institution: | Faculty of Pharmacy, Takasaki University of Health and Welfare, 60 Naka-Orui, Takasaki, Gunma 370-0033, Japan |
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Abstract: | An asymmetric total synthesis of komaroviquinone (1), which is a natural product isolated from Dracocephalum komarovi and shows novel potent trypanocidal activity, was achieved in five steps from the known starting materials. The synthetic route is shorter and more efficient than the reported methods and also useful for the scale-up synthesis. |
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