On the design of polymeric 5′-O-ester prodrugs of 3′-azido-2′,3′-dideoxythymidine (AZT) |
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| Authors: | Kolio D Troev Violeta A Mitova |
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| Institution: | a Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
b Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia, Bulgaria |
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| Abstract: | A new 5′-O-AZT prodrug was synthesized by conjugating 3′-azido-2′,3′-dideoxythymidine (AZT) with poly(oxyethylene H-phosphonate) at room temperature under Atherton-Todd reaction conditions. The acute toxicity of poly(5′-O-AZT-oxyethylene phosphate) was reduced significantly in comparison with non-immobilized AZT. |
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| Keywords: | Poly(oxyethylene H-phosphonate)s Polymer conjugates Anti-HIV prodrugs Toxicity AZT |
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