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Short and efficient access to imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives |
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| Authors: | Vincent Gaumet,Emmanuel Moreau,Abbass Taleb,Johan Neyts,Claire Lartigue,Olivier Chavignon,Alain Gueiffier,Jacques Mé tin |
| Affiliation: | a UFR Pharmacie, Université Clermont 1, Université d’Auvergne, F-63001 Clermont-Ferrand, France b Inserm, UMR 990, F-63005 Clermont-Ferrand, France c Centre Jean Perrin, F-63011 Clermont-Ferrand, France d Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium e UFR Sciences et Techniques, Université François Rabelais, F-37200 Tours, France |
| Abstract: | Access to N-protected or N-free imidazo[1,2-a]pyrrolo[3,2-c]pyridine derivatives as potential antiviral compounds was achieved in good yields from N-protected 7-amino-8-halo-2-methylimidazo[1,2-a]pyridines by catalytic coupling of terminal acetylenes under mild conditions using [PdCl2(PPh3)2] or [Cu(Phen)(PPh3)2]NO3. |
| Keywords: | Imidazo[1,2-a]pyridine Imidazo[1,2-a]pyrrolo[3,2-c]pyridine Heterocyclization Palladium catalyst Copper catalyst |
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