A facile synthesis of 2,3-azaisoindoline |
| |
| Authors: | Subas M. Sakya,Michel Van Den Berg,John M. Humphrey,Christopher J. O&rsquo Donnell |
| |
| Affiliation: | a Pfizer Global Research and Development, Neuroscience Medicinal Chemistry, Groton, CT 06355, USA
b Syncom BV, Groningen, The Netherlands |
| |
| Abstract: | 2,3-Azaisoindoline (4) was prepared via reaction of dichloride 11 with 2,4-dimethoxybenzyl amine followed by deprotection with trifluoroacetic acid and triethylsilane. Isolation of the unstable 2,3-azaisoindoline 4 was facilitated by conversion to the bis-HCl salt. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
