Straightforward synthesis of 3′-deoxy-3′,4′-didehydronucleoside-5′-aldehydes via 2′,3′-O-orthoester group elimination: a simple route to 3′,4′-didehydronucleosides |
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Authors: | Magdalena Petrová |
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Institution: | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v. v. i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic |
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Abstract: | Straightforward, high-yielding syntheses of 3′-deoxy-3′,4′-didehydronucleoside-5′-aldehydes and 3′-deoxy-3′,4′-didehydronucleosides starting from 2′,3′-O-orthoester derivatives of ribonucleosides are described. |
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Keywords: | Moffat oxidation β-Elimination Nucleoside-5&prime -aldehydes 3&prime 4&prime -Didehydronucleosides 2&prime 3&prime -O-Orthoester |
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