Thermal degradation products derived from the smoke of Salvia divinorum leaves |
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| Authors: | Zhongze Ma Ronghua Dai Lee-Yuan Liu-Chen |
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| Institution: | a Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, United States
b Department of Pharmacology and Center for Substance Abuse Research, School of Medicine, Temple University, 3420 N. Broad St, Philadelphia, PA 19140, United States |
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| Abstract: | Smoking of Salvia divinorum leaves is the most common method for its psychotropic effects. Eleven thermal degradation products, including a new neoclerodane diterpene derivative, were isolated from the smoke of S. divinorum leaves, and their structures were identified by spectroscopic methods. The isolated compounds were evaluated for their binding affinities at the opioid receptors, and salvinorin A is still the most potent kappa opioid receptor agonist. |
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| Keywords: | Salvia divinorum Salvinorin A Smoke Kappa opioid receptor |
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