Fast racemization and dynamic kinetic resolution of primary benzyl amines |
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Authors: | Yunwoong Kim Mahn-Joo Kim |
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Institution: | Department of Chemistry, Pohang University of Science and Technology, San-31 Hyojadong, Pohang 790-784, Republic of Korea |
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Abstract: | We prepared a Pd nanocatalyst (average diameter of Pd nanoparticles = 1.73 nm) displaying a remarkable activity for the racemization and dynamic kinetic resolution (DKR) of 1-methylbenzylamine. It was eight times more active than the previous best. The DKR of 1-methylbenzylamine with the Pd nanocatalyst (2 mol %) in the presence of a thermostable lipase (Novozym 435) was complete in 6 h at 70 °C. The DKRs of other benzyl amines also proceeded to completion in 6 h under similar conditions except the amount of Pd nanocatalyst. |
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