First total synthesis of achaetolide |
| |
| Authors: | S Chandrasekhar SV Balaji G Rajesh |
| |
| Institution: | Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| |
| Abstract: | The first total synthesis of achaetolide, a 10-membered macrolactone was achieved using Mitsunobu reaction and Grubbs ring-closing metathesis reaction as the key steps for ring construction. The desired stereo centres were generated by Jacobsen hydrolytic kinetic resolution, dihydroxylation and Sharpless asymmetric epoxidation reactions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
