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Ytterbium triflate catalyzed synthesis of chlorinated lactones |
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| Authors: | Salvatore Genovese Caroline Pelucchini Massimo Curini |
| Affiliation: | a Dipartimento di Scienze del Farmaco, Università ‘G. D’Annunzio’ di Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy b Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia, Italy c Edificio delle Bioscienze, Università degli Studi Magna Grecia di Catanzaro, Via Europa, Loc. Germaneto, 88100 Catanzaro, Italy |
| Abstract: | The direct synthesis of chlorolactones from differently substituted alkenoic acids, using either sodium hypochlorite or chloramine T as the source of electrophilic chlorine and ytterbium triflate hydrate as the Lewis acid is described. In both cases the reactions proceeded in good yields affording selectively five- or six-membered chlorolactones. |
| Keywords: | Lactones Lewis acids Solvent-free conditions Ytterbium triflate |
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