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Stereoselective total synthesis of stagonolide E |
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| Authors: | Gowravaram Sabitha P. Padmaja P. Narayana Reddy Surender Singh Jadav J.S. Yadav |
| Affiliation: | Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 607, India |
| Abstract: | The first total synthesis of a 10-membered macrolide, stagonolide E is described from readily available 4-penten-1-ol. The synthetic strategy involves Jacobsen’s kinetic resolution, Sharpless epoxidation, Stille-Gennari, and Yamaguchi lactonization as key reactions. |
| Keywords: | Macrolide Jacobsen&rsquo s kinetic resolution Sharpless epoxidation Stille-Gennari Yamaguchi lactonization |
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