New chemical access for pyran core embedded derivatives from bisalkenylated 1,3-diketones and 1,3-diketoesters via tandem C-dealkenylation and cyclization |
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| Authors: | T Narender S Sarkar JK Kumar |
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| Institution: | a Medicinal and Process Chemistry Division, Central Drug Research Institute (CSIR), Lucknow 226 001, UP, India
b Natural Products Chemistry Lab, CIMAP Research Centre (CSIR), Boduppal, Hyderabad 500 039, India |
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| Abstract: | New chemical access has been developed for the synthesis of pyran core embedded derivatives from 1,3-diketones and 1,3-diketoesters, in which the active methylene group of 1,3-diketone or 1,3-diketoester was alkenylated with three equivalents of alkenyl bromides in presence NaH to give bisalkenyl 1,3-diketones or 1,3-diketoesters and the resultant bisalkenyl 1,3-diketones or 1,3-diketoesters were reacted with AlCl3 at room temperature to furnish pyran core embedded derivatives in good to excellent yields. |
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| Keywords: | 1 3-Diketone 1 3-Diketoester 3 4-Dihydro-2H-pyrans AlCl3 |
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