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The traceless Staudinger ligation with fluorine-18: a novel and versatile labeling technique for the synthesis of PET-radiotracers |
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| Authors: | Marc Pretze Tim Peppel Constantin Mamat |
| Affiliation: | a Institute of Radiopharmacy, Research Center Dresden-Rossendorf, PO Box 51 01 19, D-01314 Dresden, Germany b Department of Oncologic Imaging, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2 c University of Rostock, Institute of Chemistry, Albert-Einstein-Str. 3a, D-18059 Rostock, Germany |
| Abstract: | The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18. |
| Keywords: | Radiolabeling Traceless Staudinger ligation Bioorthogonal Fluorine-18 |
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