Synthesis and spin trapping properties of 1,1-dimethyl-3-(trifluoromethyl)-1H-isoindole N-oxide |
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| Authors: | Bunpei Hatano Katsunori Miyoshi Haruna Sato Tomohiro Ito Tateaki Ogata Tatsuro Kijima |
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| Affiliation: | Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata 992-8510, Japan |
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| Abstract: | We have achieved an efficient synthesis of 1,1-dimethyl-3-(trifluoromethyl)-1H-isoindole N-oxide (2) in 39% yield by seven steps from 2-bromobenzoic acid (3). This compound serves as a spin trap reagent, giving a strong and stable ESR signal of the radical adduct of 2 in the presence of i-amyloxy radical generated by UV photolysis of i-amyl nitrite. |
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