Application of 3,3′-disubstituted xylBINAP derivatives in inter- and intramolecular asymmetric Heck/Mizoroki reactions |
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| Authors: | Danica A. Rankic |
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| Affiliation: | Department of Chemistry, University of Calgary, 2500 University Drive NW Calgary, Alberta, Canada T2N 1N4 |
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| Abstract: | 3,3′-Disubstituted xylBINAP derivatives were applied to inter- and intramolecular asymmetric Heck/Mizoroki reactions. The results from these reactions were compared to those obtained with (R)-xylBINAP, (S)-BINAP and 3,3′-disubstituted BINAP derivatives. Catalysts derived from 3,3′-disubstituted xylBINAP ligands were found to be most effective in the arylation of 2,3-dihydrofuran in terms of reaction times, conversions, and product enantioselectivity. |
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| Keywords: | Heck/Mizoroki reactions Polyene cyclization BINAP 3,3&prime -Disubstitution 3,5-Dialkyl meta effect |
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