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Iodocyclisation and rearrangement reactions of mono-protected allyl substituted guanidines |
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| Authors: | Deiniol Davies Herjan Franken Kristina Kähm Robert Nash |
| Institution: | a School of Chemistry, Bangor University, Gwynedd, LL57 2UW, UK b Phytoquest Limited, Plas Gogerddan, Aberystwyth, Ceredigion SY23 3EB, UK c Menai Organics Ltd, MENTEC, Deiniol Road, Bangor, Gwynedd LL57 2UP, UK |
| Abstract: | The iodocyclisation of a range N-allyl and N-homoallylguanidines using I2/K2CO3 has been found to lead to a series of novel heterocycles which undergo selective rearrangements on variation of the reaction conditions, and predictable protecting group migration in the presence of trifluoroacetic acid in methanol. |
| Keywords: | Iodocyclisation Ring contraction Rearrangement Guanidine |
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