An economic and efficient tetrahydrofuranylation of alcohols, imines and alkynes |
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| Authors: | Luigino Troisi Catia Granito Ludovico Ronzini Francesca Rosato Valeria Videtta |
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| Institution: | Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, via Prov.le Lecce-Monteroni, 73100 Lecce, Italy |
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| Abstract: | The tetrahydrofuranyl radical, generated by heating tetrahydrofuran in the presence of air and allyl or benzyl chloride, becomes a useful tool in order to transform the hydroxyl functions into ethers, or the C N double bond into amine, or the C-C triple bond into vinyl derivatives. A radical mechanism is proposed followed by a nucleophilic substitution for the alcohol substrate and a radical addition for the iminic and the acetylenic reactants. |
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| Keywords: | Radical reactions Alcohols Imines Alkynes Tetrahydrofuranylation |
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