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Volvalerenone A, a new type of mononorsesquiterpenoid with an unprecedented 3,12-oxo bridge from Valeriana officinalis |
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| Authors: | Peng-Cheng Wang Xin-Hui Ran Liang-Chun Li Yu-Qing Liu Jun Zhou You-Xing Zhao |
| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China b Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, PR China c Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China d Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China e Department of Chemistry, Yunnan University, Kunming 650091, PR China |
| Abstract: | Volvalerenone A (1), a new type of mononorsesquiterpenoid with an unprecedented 5/6/6 tricyclic ring system, was isolated from the roots of Valeriana officinalis, the official species of valerian used in Europe. The structure of volvalerenone A was elucidated based on its spectroscopic and single-crystal X-ray crystallography data. The absolute configuration was assigned by the computational method. A possible biosynthetic pathway of volvalerenone A was also proposed. Preliminary biological studies showed that volvalerenone A had weak inhibitory activity on acetylcholine esterase (AChE), and no enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells was observed at 50 μM. |
| Keywords: | Valeriana officinalis Valerianacae Mononorsesquiterpenoid Volvalerenone A AChE inhibitory activity |
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