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Polymer supported calixarene derivative useful for solid-phase synthesis application |
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| Authors: | Giuseppe Granata Grazia M.L. Consoli Sebastiano Sciuto |
| Affiliation: | a Istituto di Chimica Biomolecolare, C.N.R., Via Paolo Gaifami 18, I-95126 Catania, Italy b Dipartimento di Scienze Farmaceutiche—Università di Catania, Viale A. Doria 6, I-95125 Catania, Italy c Dipartimento di Scienze Chimiche—Università di Catania, Viale A. Doria 6, I-95125 Catania, Italy |
| Abstract: | A calix[4]arene derivative has been anchored to carboxyl CPG and TentaGel supports by an easily cleavable ester bond and DMT groups allow a simple loading evaluation via UV-vis spectroscopy. The loading of the calixarene on TentaGel resin has also been estimated by HR-MAS NMR experiments. The potential of the polymer supported calixarenes (9 and 10) in solid phase synthesis has been tested by condensation of four thymine nucleotide units onto the upper rim of the calix[4]arene skeleton. |
| Keywords: | Anchored-calixarene Polymeric resin Solid-phase synthesis Phosphoramidite chemistry Nucleotide-calixarene |
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