A versatile one-pot multicomponent synthesis of novel quinazolinon-2-yl-tetrasubstituted thiophenes |
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| Authors: | Hitesh B Jalani |
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| Institution: | Department of Medicinal Chemistry, B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, Sarkhej-Gandhinagar Highway, Thaltej, Ahmedabad 380 054, Gujarat, India |
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| Abstract: | Here, we report a versatile multicomponent synthesis of novel quinazolinon-2-yl-tetrasubstituted thiophenes by a one-pot reaction using different alkyl-3-aminobutenoates, isothiocyanates and 2-halomethyl quinazolinones in good to excellent yields. The reaction probably proceeds by an intramolecular 5-exo-trig cyclisation. |
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| Keywords: | Quinazolinon-2-yl-tetrasubstituted thiophenes Alkyl-3-aminobutenoates Isothiocyanates 5-exo-Trig |
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