Dehydration Mechanism and Crystallisation Behaviour of Lactose |
| |
Authors: | Garnier S Petit S Coquerel G |
| |
Institution: | (1) Université de Rouen, F-76821 Mont Saint-Aignan Cedex, France |
| |
Abstract: | The dehydration mechanism of α-lactose monohydrate was investigated by several techniques and interpreted on the basis of
structural data. Whatever the dehydration conditions (heating or use of hygroscopic organic solvents), the departure of water
molecules occurs cooperatively in channels parallel to the c axis of the initial structure. Subsequently, the reorganization
leads to the closest packing (hygroscopic metastable form, LαH) under heating or to the stable anhydrous form (LαS), probably via a nucleation and growth process in ethanol. The use of acetone as dehydrating solvent on single crystals of
α-lactose monohydrate led to the unexpected formation of single crystals of the anomeric β-lactose at room temperature, from
which the crystal structure of β-lactose could be accurately re-determined. Recrystallization experiments of anhydrous lactose
allowed to prepare N-methylpyrrolidinone and DMSO solvates of α-lactose.
This revised version was published online in August 2006 with corrections to the Cover Date. |
| |
Keywords: | crystal structure dehydration mechanism lactose solvates whiskers |
本文献已被 SpringerLink 等数据库收录! |