A dual pH and temperature responsive polymeric fluorescent sensor and its imaging application in living cells |
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Authors: | Yin Liyan He Chunsheng Huang Chusen Zhu Weiping Wang Xin Xu Yufang Qian Xuhong |
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Institution: | State key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China. |
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Abstract: | A polymeric fluorescent sensor PNME, consisting of A4 and N-isopropylacrylamide (NIPAM) units, was synthesized. PNME exhibited dual responses to pH and temperature, and could be used as an intracellular pH sensor for lysosomes imaging. Moreover, it also could sense different temperature change in living cells at 25 and 37 °C, respectively. |
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