O-selective condensation using P-N bond cleavage in RNA synthesis without base protection |
| |
| Authors: | Ohkubo Akihiro Kuwayama Yasukazu Kudo Tomomi Tsunoda Hirosuke Seio Kohji Sekine Mitsuo |
| |
| Institution: | Department of Life Science, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 226-8501, Japan. |
| |
| Abstract: | In RNA synthesis without base protection, a new method for O-selective condensation with more than 99% selectivity was developed by 6-nitro-HOBt-mediated cleavage of undesired P(III)-N bonds on nucleobase moieties. Moreover, we for the first time succeeded in synthesizing oligoRNAs without base protection. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
