Continuous solid-phase extraction and gas chromatography–mass spectrometry determination of pharmaceuticals and hormones in water samples |
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Authors: | A Azzouz B Souhail E Ballesteros |
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Institution: | 1. Department of Physical and Analytical Chemistry, E.P.S of Linares, University of Jaén, Alfonso X, El Sabio 28, 23700 Linares, Jaén, Spain;2. Department of Chemistry, Faculty of Science, University Abdelmalek Essaadi, Tétouan, Morocco |
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Abstract: | A semi-automatic flow-based method for the simultaneous determination of 9 pharmaceuticals and 3 hormones in water samples in a single analytical run is proposed. The analytes were retained on a solid-phase extraction sorbent column and 1 μL of the eluate analysed by gas chromatography in combination with electron impact ionization mass spectrometry in the SIM mode. The sorbent used, Oasis-HLB, provided near-quantitative recovery of all analytes. The proposed method was validated with quite good analytical results including low limits of detection (0.01–0.06 ng L−1 for 100 mL of water) and good linearity (r2 > 0.993) throughout the studied concentration ranges. The method provided good accuracy (recoveries of 85–103%) and precision (between- and within-day RSD values less than 7%) in the determination of the pharmaceuticals and hormones in tap, river, pond, well, swimming pool and wastewater. |
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Keywords: | Pharmaceuticals Hormones Solid-phase extraction Gas chromatography&ndash mass spectrometry Waters |
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