Acrylic-based high internal phase emulsion polymeric monolith for capillary electrochromatography |
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Authors: | Yeliz Tunç ,Ç iğdem Gö lgelioğlu,Nesrin Hasirci,Kezban Ulubayram,Ali Tuncel |
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Affiliation: | 1. Hacettepe University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, 06100 Ankara, Turkey;2. Hacettepe University, Faculty of Engineering, Chemical Engineering Department, Beytepe, 06532 Ankara, Turkey;3. Middle East Technical University, Faculty of Arts and Sciences, Department of Chemistry, 06531 Ankara, Turkey |
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Abstract: | The use of high internal phase emulsion polymers (polyHIPEs) for CEC applications has remained relatively unexplored. A few reports exist in the literature for the preparation of similar structures. In this study, polyHIPEs having high porosity, and interconnected open-cell structure, were introduced and evaluated as stationary phase for CEC. The polyHIPE monolithic columns were prepared by the in situ polymerization of isodecylacrylate (IDA) and divinylbenzene (DVB) in the continuous phase of a high internal phase emulsion (HIPE). Due to its well-defined polyHIPE structure with interconnected micron size spherical voids, the columns synthesized with different initiator concentrations were successfully used for the separation of alkylbenzenes. Furthermore, the columns indicated a strong electroosmotic flow (EOF) without any additional EOF generating monomer probably due to the presence of ionizable sulfate groups coming from the water-soluble initiator used in the preparation of polyHIPE matrix. The best chromatographic performance in the separation of alkylbenzenes was achieved by using 70% ACN in the mobile phase with high column efficiency (up to 200 000 plates/m). |
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Keywords: | Monolithic columns PolyHIPE monoliths Open-cell structure Capillary electrochromatography |
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