Copper-catalyzed tandem conjugate addition-electrophilic trapping: ketones, esters, and nitriles as terminal electrophiles |
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| Authors: | Agapiou Kyriacos Cauble David F Krische Michael J |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA. |
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| Abstract: | Exposure of enone substrates 1a-18a, which possess appendant ketone, ester, and nitrile moieties, to Et2Zn in the presence of catalytic Cu(OTf)2/P(OEt)3 provides the cyclized products in good to excellent yields and diastereoselectivities. These results represent the first use of ketones, esters, and nitriles as terminal electrophiles in Cu-catalyzed conjugate addition-electrophilic trapping. |
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