Modification of gamma-carbolines with N-substituted propionamides as a new approach to mitoprotective agents |
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| Authors: | S O Bachurin D V Vinogradova E F Shevtsova T V Goreva T A Epishina A Yu Aksinenko V B Sokolov |
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| Institution: | 1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi pr-d, 142432, Chernogolovka, Moscow Region, Russian Federation
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| Abstract: | An approach to the modification of biologically active gamma-carbolines with the N-substituted propionamide fragments by the reaction of N-substituted acrylamides with gamma-carbolines catalyzed by cesium fluoride has been suggested. The compounds synthesized were studied for the influence on the functional characteristics of brain mitochondria, in particular, on the membrane potential, calcium-induced “swelling” and calcium capasity of the rat brain mitochondria. |
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