| {苯基-[(吡啶-4-羰基)-氨基]-甲基}-膦酸二烷基酯的合成与波谱表征 |
| |
| 引用本文： | 方华,方美娟,留筱厦,许鹏翔,赵玉芬. {苯基-[(吡啶-4-羰基)-氨基]-甲基}-膦酸二烷基酯的合成与波谱表征[J]. 有机化学, 2005, 25(4): 466-469 |
| |
| 作者姓名： | 方华 方美娟 留筱厦 许鹏翔 赵玉芬 |
| |
| 作者单位： | 1. 厦门大学化学化工学院福建省化学生物学省重点实验室,厦门,361005
2. 厦门大学化学化工学院福建省化学生物学省重点实验室,厦门,361005;清华大学生命有机磷化学及化学生物学教育部重点实验室,北京,100084 |
| |
| 摘 要： | α-氨基膦酸及其衍生物作为天然氨基酸的含磷类似物, 具有多种生物活性, 它的合成与性质的研究引起人们的浓厚兴趣. 合成了一系列含磷化合物, 产物经元素分析、红外光谱、核磁共振、质谱鉴定, 并初步研究这些化合物的抗菌与抗肿瘤生物活性.
|
| 关 键 词： | α-氨基膦酸 合成 波谱表征 生物活性 |
| 收稿时间： | 2004-06-07 |
| 修稿时间： | 2004-06-07 |
Synthesis and Spectral Characterization of {Phenyl-[(pyridine-4-carbonyl)amino]methyl}phosphonic Acid Dialkyl Ester |
| |
| FANG Hua,FANG Mei-Juan,LIU Xiao-Xia,XU Peng-Xiang,ZHAO Yu-Fen. Synthesis and Spectral Characterization of {Phenyl-[(pyridine-4-carbonyl)amino]methyl}phosphonic Acid Dialkyl Ester[J]. Chinese Journal of Organic Chemistry, 2005, 25(4): 466-469 |
| |
| Authors: | FANG Hua FANG Mei-Juan LIU Xiao-Xia XU Peng-Xiang ZHAO Yu-Fen |
| |
| Affiliation: | ( Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xia-men University, Xiamen 361005)( Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department ofChemistry, Tsinghua Univer-sity, Beijing 100084) |
| |
| Abstract: | α-Aminophosphonic acids and their derivates, as phosphorous analogs of amino acid, have attracted much attention because they show wide biological activities. In this paper, the title compounds, {phenyl-[(pyridine-4-carbonyl)amino]methyl}phosphonic acid dialkyl esters, were synthesized via Mannich reaction and peptide coupling reaction. Their structures were confirmed by elemental analysis, IR, 1H NMR, 13C NMR and MS spectra, and the antibacterial and antitumor activities of these compounds were given in this paper. |
| |
| Keywords: | α-aminophosphonic acid synthesis spectral characterization biological activ-ity |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
|
点击此处可从《有机化学》下载全文 |
|
