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MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes |
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| Authors: | Miyake Yoko Togashi Humika Tashiro Mitsuru Yamaguchi Hiroshi Oda Shuji Kudo Megumi Tanaka Yoshiyuki Kondo Yoshinori Sawa Ryuichi Fujimoto Takashi Machinami Tomoya Ono Akira |
| Affiliation: | Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-ohsawa 1-1, Hachioji, Tokyo 192-0397 Japan. |
| Abstract: | The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs. |
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