Synthesis of N6-substituted adenines from 3-methylxanthine |
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Authors: | P M Kochergin L V Persanova E V Aleksandrova |
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Institution: | (1) Center for the Chemistry of Medicinals, All-Russia Chemico-pharmaceutical Scientific Research Institute, 119815 Moscow, Russia;(2) State Institute for Hematological and Medicinal Materials, 109044 Moscow, Russia;(3) Zaporozhe State Medical University, 330074 Zaporozhe, Ukraine |
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Abstract: | A series of 6-arylalkyl(hetarylalkyl, cycloalkyl, carboxyalkyl)amino-7-benzyl-2-chloropurines have been synthesized from 3-methylxanthine via the reaction of the intermediate 7-benzyl-2,6-dichloropurine with amines and aminoacids. N6-benzyladenine, N6-(-furfuryl)adenine (kinetin), and N-(purinyl)glycine have been obtained via the catalytic hydrogenation of 7-benzyl-6-benzyl(furfuryl, carboxymethyl)amino-2-chloropurines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, 529–532, April, 2000. |
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Keywords: | benzyladenine dichlorobenzylpurine substituted adenines kinetin methylxanthine |
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