Time-resolved laser-induced fluorescence spectroscopy for enhanced demarcation of human atherosclerotic plaques |
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| Authors: | S Andersson-Engels J Johansson U Stenram K Svanberg S Svanberg |
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| Affiliation: | Department of Physics, Lund Institute of Technology, Sweden. |
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| Abstract: | We report on the enhanced demarcation between human atherosclerotic plaques and normal vessel wall obtained using time-resolved detection of laser-induced fluorescence rather than the customary time-integrated monitoring technique. A frequency-doubled mode-locked and cavity-dumped continuous wave dye laser was used for picosecond pulse generation at 320 nm, and photon-counting techniques were employed for the time-resolved signal monitoring from human aorta samples in vitro. Implications for imaging fluorescence angioscopy and spectroscopic guidance in laser ablation of plaque are indicated. |
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