Signal Intensity for Contrast Enhancement as a Function of the Molarity of Gadolinium-Based MRI Contrast Media |
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| Authors: | Seung-Man Yu Kyung-Rae Dong Youn-Sang Ji Eun-Hoe Goo Woon-Kwan Chung Jong-Woong Lee Chong-Hwan Choe |
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| Institution: | (1) Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea;(2) Department of Radiological Technology, Gwangju Health College University, 683, Shinchang-dong, Gwangsan-gu, Gwangju, 506-701, Republic of Korea;(3) Department of Nuclear Engineering, Chosun University, Gwangju, Republic of Korea;(4) Department of Physics, Soonchunhyang University, Asan, Republic of Korea;(5) Department of Radiology, Kyung Hee University Hospital at Gangdong, Gangdong, Republic of Korea;(6) Department of Electronics and Communications Engineering, Gwangwoon University, Seoul, Republic of Korea;(7) Department of White Memorial Medical Center, Los Angeles, CA, USA |
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| Abstract: | Gadolinium is the central metal that is used as magnetic resonance imaging (MRI) contrast media. Because the metal has toxicity
on its own, it causes fibrosis or sclerosis of skin or internal organs, which may lead to disability in joint movement, or
even death in the worst case. In the current study, the T
1 contrast media, Dotarem, was diluted to various molarities to measure the signal intensity of T
1-weighted images as a function of the molarity. The molarity that showed the maximum measurement value of the signal intensity
was examined to determine the proper amount of contrast media injected for the MRI scan. The change in the intensity of the
signal from the tumor tissue was determined based on the passage of time after injection. The distribution of the maximum
signal intensities depending on the time to repeat showed that the signal distribution had >95% of the maximum values when
the dilution concentration was in the range of 0.00095–0.00135 mmol/ml. Thus, it is most desirable when 0.084 mmol/kg (patient
weight) of contrast media is injected. In experiments involving tumors 0.084, 0.1, and 0.15 mmol/kg were injected to measure
the average signal intensity for each molarity. Compared to the signal intensity at a molarity of 0.084 mmol/kg, the three
patient’s signal intensities were measured to increase by 6.2, 7.6, and 5.7% at a molarity of 0.1 mmol/kg, and by 21.4, 18.8,
and 17.7% at a molarity of 0.15 mmol/kg. However, according to the correlation between the contract media injection amount
and the signal intensity increase, the contrast effect was not improved much despite the increase in the injection amount
by 19.04 and 78.5%. This study revealed that the optimal level of contrast media of 0.084 mmol/kg body weight should be administered
by considering the body weight of patients and the effects of media to reduce side effects of a high dose of contrast media
and to prevent environmental pollution. |
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