Characterization of human cartilage in degenerated spine disease with differential scanning calorimetry |
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Authors: | L Mécs Z Aigner G Sohár Piroska Szabó-Révész K Tóth |
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Institution: | 1.Department of Orthopaedics,University of Szeged, Faculty of Medicine,Szeged,Hungary;2.Department of Pharmaceutical Technology,University of Szeged, Faculty of Pharmacy,Szeged,Hungary |
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Abstract: | The purpose of this study was to further characterize the altered metabolism spondylolisthesis that promotes disease progression.
Degenerative human cartilage (intervertebral disc, facet joint and vertebral end-plate) was obtained during 15 posterior lumbar
spine interbody fusion procedures performed at the University of Szeged. The thermal properties of samples were determined
by differential scanning calorimetry (Mettler-Toledo DSC 821e). Greatest change in the enthalpy was observed in the intervertebral disc samples: −1600.78 J g−1. Denaturation caused by heating in the normal human hyaline cartilage needed −1493.31 J g−1 energy. Characterization of the altered metabolism that promotes disease progression should lead to future treatment options. |
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Keywords: | DSC enthalpy human hyaline cartilage spondylolisthesis |
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