| 新型吡咯并[2,1-f][1,2,4]三嗪酪氨酸激酶抑制剂的设计与合成 |
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| 引用本文： | 徐中轩,蒋达洪,陈元伟. 新型吡咯并[2,1-f][1,2,4]三嗪酪氨酸激酶抑制剂的设计与合成[J]. 合成化学, 2009, 17(3) |
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| 作者姓名： | 徐中轩 蒋达洪 陈元伟 |
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| 作者单位： | 中国科学院,成都有机化学研究所,不对称合成与手性技术四川省重点实验室,四川,成都,610041;中国科学院,研究生院,北京,100049;中国科学院,成都有机化学研究所,不对称合成与手性技术四川省重点实验室,四川,成都,610041 |
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| 摘 要： | 以对甲基苯磺酰甲基异腈和反-2-丁烯酸甲酯为原料,经过11步反应合成了7个4,5,6-三取代的新型吡咯并[2,1-f][1,2,4]三嗪酪氨酸激酶抑制剂,总收率3.2%～10.0%,其结构经1H NMR和MS 表征.
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| 关 键 词： | 酪氨酸激酶抑制剂 三嗪 设计 药物合成 |
Design and Synthesis of Novel Pyrrolo[2,1-f][1,2,4] triazines as Tyrosine Kinase Inhibitor |
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| XU Zhong-xuan,JANG Da-hong,CHENG Yuan-wei. Design and Synthesis of Novel Pyrrolo[2,1-f][1,2,4] triazines as Tyrosine Kinase Inhibitor[J]. Chinese Journal of Synthetic Chemistry, 2009, 17(3) |
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| Authors: | XU Zhong-xuan JANG Da-hong CHENG Yuan-wei |
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| Affiliation: | 1. Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province;Chengdu Institute of Organic Chemistry;Chinese Academy of Sciences;Chengdu 610041;China;2. Graduate University of Chinese Academy of Sciences;Beijing 100049;China |
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| Abstract: | Seven novel 4,5,6-trisubtituted pyrrolo[2,1-f][1,2,4]triazines as tyrosine kinase inhibitors in total yileds of 3.2%~10.0% were synthesized from tosylmethyl isocyanide and trans-2-butenic acid methyl ester by a eleven-step reaction. The structures were characterized by 1H NMR and MS. |
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| Keywords: | tyrosine kinase inhibitor triazine design drug synthesis |
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