Clerodane diterpenoids and flavonoids with NGF-potentiating activity from the aerial parts of Baccharis gaudichaudiana |
| |
Authors: | Guo Yuanqiang Li Yushan Xu Jing Li Ning Yamakuni Tohru Ohizumi Yasushi |
| |
Institution: | Department of Pharmaceutical Sciences, Nankai University, Tianjin, P.R. China. victgyq@163.com |
| |
Abstract: | A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2-4) and three known flavones (5-7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|