Ti/Pd bimetallic systems for the efficient allylation of carbonyl compounds and homocoupling reactions |
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| Authors: | Millán Alba Campaña Araceli G Bazdi Btissam Miguel Delia de Cienfuegos Luis Alvarez Echavarren Antonio M Cuerva Juan M |
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| Affiliation: | Department of Organic Chemistry, Faculty of Sciences, University of Granada, Granada, Spain. |
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| Abstract: | The allylation, crotylation and prenylation of aldehydes and ketones with stable and easily handled allylic carbonates is promoted by a Ti/Pd catalytic system. This Ti/Pd bimetallic system is especially convenient for the allylation of ketones, which are infrequent substrates in other related protocols, and can be carried out intramolecularly to yield five- and six-membered cyclic products with good stereoselectivities. In addition, Ti/Pd-mediated reductions and Würtz-type dimerisation reactions can be readily carried out from allyl carbonates and carboxylates. |
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| Keywords: | allylation palladium synthetic methods titanium Würtz reaction |
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