Lewis acid catalyzed benzylic C-H bond functionalization of azaarenes: addition to enones |
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| Authors: | Komai Hirotomo Yoshino Tatsuhiko Matsunaga Shigeki Kanai Motomu |
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| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | A Lewis acid catalyzed benzylic C-H bond functionalization of alkyl-substituted azaarenes is described. Sc(OTf)(3) and Y(OTf)(3) promoted the direct addition of alkyl-substituted azaarenes and benzoxazole to enones and an α,β-unsaturated N-acylpyrrole. Products were obtained in 60-96% yield. |
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