| 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuna impatiens |
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| 作者单位： | Peng SUN，Yang Hua YI，Ling LI，Min GUI，Hai Feng TANG，Da Zhi ZHANG，Shi Long ZHANG，Research Center for Marine Drugs，Pharmacy School，Second Military Medical University，Shanghai 200433 Division of Antitumor Pharmacology，State Key Laboratory of Drug Research，Shanghai Institute of Materia Medica，Shanghai Institutes for Biological Sciences，Chinese Academy of Sciences，Shanghai 201203 Department of Pharmacy，Xijing Hospital，4th Military Medical University，Xi'an 710032 Department of Organic Chemistry，Pharmacy School，Second Military Medical University，Shanghai 200433 |
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| 摘 要： | A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively.
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17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuna impatiens |
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| Abstract: | |
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| Keywords: | Sea cucumber Holothuria impatiens 17-dehydroxyholothurin A triterpene glycoside |
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