Halothane changes the domain structure of a binary lipid membrane |
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Authors: | Weinrich Michael Nanda Hirsh Worcester David L Majkrzak Charles F Maranville Brian B Bezrukov Sergey M |
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Affiliation: | National Center for Medical Rehabilitation Research, Eunice Kennedy Shriver Institute of Child Health and Human Development, Bethesda, Maryland, United States. Mw287k@nih.gov |
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Abstract: | X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture. |
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