Palladium and copper cocatalyzed tandem N-H/C-H Bond functionalization: synthesis of CF3-containing indolo- and pyrrolo[2,1-a]isoquinolines |
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Authors: | Sun Lei-Lei Liao Zhi-Yong Tang Ri-Yuan Deng Chen-Liang Zhang Xing-Guo |
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Institution: | College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China. |
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Abstract: | A palladium- and copper-catalyzed tandem N-H/C-H bond functionalization reaction of ortho-(2-chlorovinyl)bromobenzenes with indoles and pyrroles has been developed. A variety of CF(3)-containing indolo- and pyrrolo2,1-a]isoquinolines were prepared in moderate to good yields via the cyclization of 1-bromo-2-(2-chloro-3,3,3-trifluoroprop-1-enyl)benzenes with indoles and pyrroles. |
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