Composition,structural characteristics,and antitumor properties of polysaccharides from the brown algae <Emphasis Type="Italic">Dictyopteris polypodioides</Emphasis> and <Emphasis Type="Italic">Sargassum</Emphasis> sp. |
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| Authors: | R V Sokolova S P Ermakova S M Awada T N Zvyagintseva H M Kanaan |
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| Institution: | (1) Pacific Institute of Bioorganic Chemistry, Far-East Division, Russian Academy of Sciences, 690022 Vladivostok, Prosp. 100-Letiya Vladivostoka, 159, Russia;(2) Laboratory of Biotechnology of Natural Substances and Health Products, Faculty of Pharmacy, Lebanese University, Beirut, Lebanon |
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| Abstract: | The polysaccharide compositions of the brown algae Dictyopteris polypodioides and Sargassum sp. from the Mediterranean Sea were determined. The principal polysaccharide of the studied algae (about 12% of the dry alga
weight) was alginic acid. The content of water-soluble polysaccharides was low. The amount of fucoidan was less than 1% of
the dry alga weight; of neutral polysaccharides, less than 0.25%. The monosaccharide compositions of fucoidans and neutral
polysaccharides were investigated. Experiments on soft agar-agar models showed that fucoidans from D. polypodioides and Sargassum sp. exhibited antitumor activity against RPMI-7951 human melanoma cells. |
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