Efficient synthesis of scutellarein |
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| Authors: | Righi Giuliana Silvestri Ilaria Proietti Barontini Maurizio Crisante Fernanda Di Manno Andrea Pelagalli Romina Bovicelli Paolo |
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| Institution: | C.N.R. Institute of Biomolecular Chemistry (ICB), Unity of Rome, c/o Department of Chemistry, Sapienza University of Rome, p.le A. Moro 5, 00185 Rome, Italy. |
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| Abstract: | Scutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of scutellarein and its methylated derivative. The new features are the innovating method to afford flavones from flavanones and the A-ring regioselective bromination step that lead to the target molecule by a facile and high-yielding pathway. |
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