Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy |
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| Authors: | Kieltyka Roxanne E Bastings Maartje M C van Almen Geert C Besenius Pol Kemps Erwin W L Dankers Patricia Y W |
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| Institution: | Institute for Complex Molecular Systems, and Laboratory of Chemical Biology, Eindhoven University of Technology (TU/e), PO Box 513, 5600 MB, Eindhoven, The Netherlands. |
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| Abstract: | A convenient method to prepare supramolecular bioconjugates in a facile and scalable manner is by a modular approach, whereby self-assembling units and peptides are coupled using oxime chemistry. We here report syntheses of bioactive ureidopyrimidinone-based peptide conjugates, and their resultant self-assembly into fibrous structures. |
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